(Apr. 3, 2009) — Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.

Les omégas 3 trouvés dans les poissons réduisent la taille des tumeurs et rehaussent les effets positifs de la chimio à base de cisplatine tout en limitant les effets secondaires. Des expériences sur des rats supportent les nombreux bénifices associés avec la prise d'oméga-3.


Professor A. M. El-Mowafy led a team of researchers from Mansoura University, Egypt, who studied DHA's effects on solid tumours growing in mice, as well as investigating how this fatty acid interacts with cisplatin, a chemotherapy drug that is known to cause kidney damage. El-Mowafy said, "DHA elicited prominent chemopreventive effects on its own, and appreciably augmented those of cisplatin as well. Furthermore, this study is the first to reveal that DHA can obliterate lethal cisplatin-induced nephrotoxicity and renal tissue injury."

De plus, cette étude révèle pour la première fois que le DHA annulle les effets néfastes et mortels de la cisplatine sur les reins.

DHA is an omega-3 fatty acid that is commonly found in cold-water fish oil, and some vegetable oils. It is a major component of brain gray matter and of the retina in most mammalian species and is considered essential for normal neurological and cellular developments. According to the authors, "While DHA has been tentatively linked with protection against cardiovascular, neurological and neoplastic diseases, there exists a paucity of research information, in particular regarding its interactions with existing chemotherapy drugs". The researchers found that, at the molecular level, DHA acts by reducing leukocytosis (white blood cell accumulation), systemic inflammation, and oxidative stress – all processes that have been linked with tumour growth.

Les chercheurs ont découverts que la DHA réduit les accumulations de cellules blanches, le stress oxydatif et l'inflammation systémique tous ces processus étant reliés avec la croissance des tumeurs.

El-Mowafy and his colleagues have called for greater deployment of omega-3 in the fight against cancer. They write, "Our results suggest a new, fruitful drug regimen in the management of solid tumors based on combining cisplatin, and possibly other chemotherapeutics, with DHA".

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recette pour cuire le saumon :

3 lbs (1.4 kg) saumon entier
Beurre
1 c.à thé (5 ml) beurre à l'ail
1 c.à soupe (15 ml) moutarde de Dijon
1 oignon
Sel
Poivre
EtapesPréchauffer le four à 400°F (200°C).


Beurrer un papier en aluminium assez grand pour envelopper le saumon. Coucher le poisson sur le papier en aluminium.


Dans un petit bol, mêler le beurre à l'ail et la moutarde. Etendre sur le saumon.


Ajouter les oignons en rondelles. Saler et poivrer au goût.


Bien refermer le papier en aluminium et sceller. Cuire au four à 400°F (200°C). Calculer 15 minutes par pouce d'épaisseur de votre saumon (1 pouce = 2,5 centimètres).


Pour un morceau de saumon: Suivre le même procédé mais diminuer à 1/2 c.à thé (2 g) de beurre à l'ail mêlé a 1 c.à thé (5 ml) de moutarde de Dijon.