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 De la poudre de raisins gelés séchés...

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Nombre de messages : 16834
Date d'inscription : 23/02/2005

MessageSujet: Re: De la poudre de raisins gelés séchés...   Jeu 1 Jan 2009 - 13:59

The investigators, who report their findings in the January 1, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, also teased apart the cell signaling pathway associated with use of grape seed extract that led to cell death, or apoptosis. They found that the extract activates JNK, a protein that regulates the apoptotic pathway.

Les chercheurs rapportent dans le journal Clinical Cancer research un taux élevé de suicide cellulaire en association avec une consommation d'extrait de noyeaux de raisins. Ils ont trouvé que l,extrait active la protéine JNK qui régule le chemin apoptique.

While grape seed extract has shown activity in a number of laboratory cancer cell lines, including skin, breast, colon, lung, stomach and prostate cancers, no one had tested the extract in hematological cancers nor had the precise mechanism for activity been revealed.

L'extrait de noyeaux (ou de graines ?) de raison a démontré une activité dans de nombreuses sortes de cellules cancéreuses incluant :prostate et estomac personne n'avait testé l'extrait de noyeaux de raisin pour les cellules cancéreuses du

"These results could have implications for the incorporation of agents such as grape seed extract into prevention or treatment of hematological malignancies and possibly other cancers," said the study's lead author, Xianglin Shi, Ph.D., professor in the Graduate Center for Toxicology at the University of Kentucky.

"What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category," he said.

Shi adds, however, that the research is not far enough along to suggest that people should eat grapes, grape seeds, or grape skin in excess to stave off cancer. "This is very promising research, but it is too early to say this is chemo-protective."

Hematological cancers – leukemia, lymphoma and myeloma – accounted for an estimated 118,310 new cancer cases and almost 54,000 deaths in 2006, ranking these cancers as the fourth leading cause of cancer incidence and death in the U.S.

Given that epidemiological evidence shows that eating vegetables and fruits helps prevent cancer development, Shi and his colleagues have been studying chemicals known as proanthocyanidins in fruits that contribute to this effect. Shi has found that apple peel extract contains these flavonoids, which have antioxidant activity, and which cause apoptosis in several cancer cell lines but not in normal cells. Based on those studies, and findings from other researchers that grape seed extract reduces breast tumors in rats and skin tumors in mice, they looked at the effect of the compound in leukemia cells.

Avec la preuve que manger des fruits et des légumes prévient le développement du cancer, Shi et ses collègues ont étudiés les éléments chimiques comme le proanthocianidines dans les fruits. shi a découvert que la pelure de pomme contient des flavonoïdes qui ont une activité antioxydante et cause apoptose dans plusieurs cancers mais non dans les cellules normales. Basé sus ses études, l'extrait de noyeaux de raisins réduit les tumeurs du chez le rat, les tumeurs de la chez la souris. Ils étudient les effets pour le cancer du

Using a commercially available grape seed extract, Shi exposed leukemia cells to the extract in different doses and found the marked effect in causing apoptosis in these cells at one of the higher doses.

They also discovered that the extract does not affect normal cells, although they don't know why.

The researchers then used pharmacologic and genetic approaches to determine how the extract induced apoptosis. They found that the extract strongly activated the JNK pathway, which then led to up-regulation of Cip/p21, which controls the cell cycle.

They checked this finding by using an agent that inhibited JNK, and found that the extract was ineffective. Using a genetic approach – silencing the JNK gene – also disarmed grape seed extract's lethal attack in leukemia cells.

"This is a natural compound that appears to have relatively important properties," Shi said.

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MessageSujet: Re: De la poudre de raisins gelés séchés...   Jeu 28 Aoû 2008 - 11:55

g. 27, 2008) — New research strongly suggests that a mix of preventative agents, such as those found in concentrated black raspberries, may more effectively inhibit cancer development than single agents aimed at shutting down a particular gene.

Une nouvelle recherche suggère fortement qu'un mélange d'agents préventifs comme des molécules truovées dans un concentré de mûres peut inhiber le cance rplus efficacement qu'un agent simple comme un médicament qui serait employé pour bloquer un seul gène.

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MessageSujet: De la poudre de raisins gelés séchés...   Mer 14 Nov 2007 - 21:32

(Nov. 14, 2007) — Low doses of freeze-dried grape powder inhibit genes linked to the development of sporadic colorectal cancer, University of California, Irvine cancer researchers found.

De petites doses de raisins séchés et gelés inhibent les gènes liés au développement du cancer du sporadique.

The study suggests that a diet rich in grapes may help prevent the third most common form of cancer, one that kills more than a half a million people worldwide each year. Around 7 percent of all Americans develop colon cancer during their lifetimes.

Led by Dr. Randall Holcombe, director of clinical research at the Chao Family Comprehensive Cancer Center at UC Irvine, the study followed up on previous in vitro studies showing that resveratrol, a nutritional supplement derived from grape extract, blocks a cellular signaling pathway known as the Wnt pathway. The Wnt pathway has been linked to more than 85 percent of sporadic colon cancers, which is the most common form of colon cancer.

The UC Irvine researchers conducted their study with colon cancer patients. One group was given 20 milligrams daily of resveratrol as a pill; another drank 120 grams daily of grape powder mixed in water; and a third drank 80 grams daily of grape powder.

While the supplements did not have an impact on existing tumors, biopsied colon tissue showed that Wnt signaling in the patients taking 80 grams of grape powder was significantly reduced. Similar changes were not seen in patients taking the higher dose of grape powder or the resveratrol pills.

The researchers aren’t certain why the lower dose of grape powder was more effective than the higher one. However, they believe that the active components in the grapes may have different effects at low dose than they do at high dose, which is a fairly common finding in nutritional studies.

Holcombe and his colleagues will present their study results Nov. 16 at the Society for Integrative Oncology’s Fourth International Conference in San Francisco.

“This is truly exciting, because it suggests that substances in grapes can block a key intracellular signaling pathway involved in the development of colon cancer before a tumor develops,” said Holcombe.

C'est vraiment excitant parce que cela suggère que des substances dans les raisins bloquent un chemin cellulaire clé impliqué dans le développement du cancer du avant qu'une tumeur se développe.

The resveratrol chemical is found naturally in grape skins, wine and also in peanuts. It is unclear why resveratrol alone was not as effective, but Holcombe believes that other grape chemicals may supplement or boost resveratrol’s efficacy.

Eighty grams of grape powder equal a half glass of wine or 1 pound of grapes, which is equivalent to three dietary servings of grapes, according to the USDA. Holcombe and his colleagues are currently designing a clinical cancer prevention study to see how a daily diet of 1 pound of grapes affects Wnt signaling.

80 grammes de poudre de raisin, l'équivalent de la moiié de verre de vin ou 1 livre de raisins. Holcombe es tses collègues mettent sur pied un esai clinique pour voir comment cette diète quotidienne d'une livre de raisins va affecter le chemin WNT.

This study follows an epidemiological survey by Holcombe, Dr. Jason Zell, assistant clinical professor of medicine at UC Irvine, and Dr. Hoda Anton-Culver, chair of epidemiology and director of UC Irvine’s Cancer Surveillance Program. In this study of 499 colorectal cancer patients, they found that moderate wine consumption before developing colon cancer was associated with improved survival outcomes among those patients with family history of colorectal cancer.

The researchers found that 75 percent of such patients were alive after 10 years of initial diagnosis, compared to 47 percent of such patients who did not regularly drink wine. Study results appeared in the October 2007 issue of Nutrition and Cancer.

Les chercheurs ont trouvé que 75% des patients étaient encore en vie après 10 ans du diagnostic initial comparé à 47 % des patients qui ne boivent pas régulièrement du vin.

“Our epidemiologic study suggests that wine consumption may influence survival among a subset of colorectal cancer patients, specifically those with family history of the disease,” Zell said. “These findings could reflect unique genetic and environmental interactions among familial colorectal cancer patients, but further studies are needed to test this theory. Studies such as Dr. Holcombe’s with grape powder extract and resveratrol are important as they offer potential explanations for our findings.”

Notre étude sugère que la consommation de vin peut influencer la survie parmi les patients du cancer du spéciallement ceux avec une histoire de famille de cancer du

Holcombe said researchers have known for a long time that there is a link between diet and cancer. “These findings suggest that we should do additional research and clinical studies on grapes and other natural products that may prove effective in helping to prevent cancer,” he said.

The grape study received support from the California Table Grape Commission and the UCLA Bionutrition Unit. The authors declare no financial interest or conflicts of interest.
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