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 Que nous dit la bourse ?

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AuteurMessage
Denis
Rang: Administrateur
Denis


Nombre de messages : 17118
Date d'inscription : 23/02/2005

Que nous dit la bourse ? Empty
MessageSujet: Que nous dit la bourse ?   Que nous dit la bourse ? Icon_minitimeMer 24 Aoû 2011 - 6:07

Dans cet article, un journaliste financier recommande des valeurs boursières dans les compagnies pharmaceutiques qui selon lui devraient monter. Or ces valeurs vont monter si la compagnie a un médicament qui agit contre le cancer. Je mets ça ici mais je n'ai pas tout lu. J'ai l'intention d'en traduire les bouts les plus utiles pour nous parce que ça me semble intéressant. Il est question entre autres de la perifosine qui intéressait au moins Achille qui avait posé des questions là-dessus et je crois qu'il y a quelques réponses à ce sujet et même des mentions de médicaments dont je n'avais pas entendu parler et qui semble prometteurs.


In this article, as the title suggests, we are trying to isolate biotech companies who have products in development that will actually change the face of medicine for certain ailments and diseases. That being the case, the companies in question must have products or technologies that address diseases and ailments that are severe in nature and that address unmet needs. There are a multitude of companies working on numerous new drugs and ideas, but for this article we want to only focus on those that will have the biggest impact for the patient, and at the same time, the investor. Needless to say, these companies will carry a much higher level of risk. That being said, they also carry a huge potential for rewards if they prove to be successful.

RXi Pharmaceuticals (RXII): RXII is yet another biotechnology company that has the ability to really make a difference in the world of medicine. The company was formerly known as Argonaut Pharmaceuticals, Inc., and changed its name to RXi Pharmaceuticals Corporation in November 2006. RXII’s lead product candidate is NeuVax, which stimulates T cells in a highly specific manner to target cells associated with breast cancer.

Neuvax qui stimule les cellules T d'une manière hautement spécifique pour cibler les cellules associées avec le cancer du Que nous dit la bourse ? 307163

Breast cancer is a very big issue; according to the National Cancer Institute, over 200,000 women in the U.S. are diagnosed with breast cancer annually. Of these women, about 75% test positive for Human Epidermal growth factor Receptor 2 (IHC 1+, 2+ or 3+). Only 25% of all breast cancer patients, those with HER2 3+, are eligible for a drug called Herceptin (Trastuzumab) which is a Roche-Genentech product. NeuVax targets the remaining 50% of HER2 positive patients (HER2 1+ and 2+), who achieve remission with current standard of care, but have no available HER2 targeted adjuvant treatment options to maintain their disease-free status with low to intermediate HER2.

What this boils down to is that the market for their product would be big. The key to RXII’s future is the recent results from the latest trials where NeuVax was given to intermediate HER2 positive patients. Results were spectacular as the recurrence rate for the control group was 22.2% while the recurrence rate for the NeuVax + Trastuzumab group was 0% for a 36-month period. That is quite an impressive result. Based on a successful Phase II trial, which achieved the primary endpoint of disease-free survival, the FDA granted a Special Protocol Assessment for its Phase III study. This Phase III multicenter trial is expected to commence in the first half of 2012.

As of June 30, 2011, cash, cash equivalents and short-term investments totaled $17.9 million, compared with cash and cash equivalents of $6.9 million at December 31, 2010. This $11.0 million increase is attributable to the closing of two underwritten public offerings that provided net cash proceeds of $18.2 million after fees, offset by net cash used in operating activities of $7.2 million for the six months ended June 30, 2011.

Research and development expenses increased to $2.7 million in the second quarter of 2011 from $2.3 million in the second quarter of 2010, and increased to $4.8 million for the first six months of 2011 from $4.2 million for the first six months of 2010. The increase in research and development expenses for the second quarter of 2011 compared with the second quarter of 2010 was primarily due to an increase in research and development cash expenses due to a ramp-up in NeuVax. The question will be if RXII will have enough cash to burn through as they plow through the Phase III trials. In the end, though, if their product can help fight against breast cancer on the level they predict, it should be a winner for investors.

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Celldex (CLDX): Celldex is a biotechnology company focused on the discovery, development and commercialization of targeted immunotherapies. The core focus for the company will be these immunotherapies and their ability to treat cancer. CLDX will attempt to change the world of medicine with its vaccine, Rindopepimut, which is being tested against the most common and aggressive form of brain cancer. If successful, the vaccine also has the potential be to used in other types of cancer, including breast, ovarian, metastatic prostate, colorectal, and head & neck.

CLDX veut changer le monde de la médecine avec son vaccin, le Rindopepimut, qui est testé contre la forme l aplu socmmune et la plus agressive du cancer du Que nous dit la bourse ? 307180 . Si ça réussit le vaccin pourra être aussi utilisé dans d'autres types de cancer Que nous dit la bourse ? 307163 Que nous dit la bourse ? 307215 Que nous dit la bourse ? 307098 Que nous dit la bourse ? 307141 Que nous dit la bourse ? 308394

These cancer vaccines are the new and upcoming treatments, and hopefully will provide a new standard of care for patients. The Phase II studies provided good results, and the company is preparing to enter a Phase III clinical trial. If CLDX is finally successful, the vaccine Rindopepimut could easily be used as the new treatment for all types of cancer.

SI CDLX réussit, il pourra être facilement utilisé pour tout type de cancer.

At June 30, 2011, the company had cash, cash equivalents and marketable securities of $71.2 million. The Company incurred a loss of $20.3 million for the six months ended June 30, 2011. The net cash used in operations for the six months ended June 30, 2011 was $18.2 million. CLDX believes that the cash, cash equivalents, and cost control will be sufficient to fund the estimated working capital requirements and planned operations for at least the next 12 months.

The company raised net proceeds of $35.9 million from the sale of its common stock during the three months ended June 30, 2011. During the next 12 months, the company expects to take further steps to raise additional capital to meet its long-term liquidity needs. The issue is that the company is not quite sure how they will complete this. The will try to license their technology or find a business partner to help absorb some of the cost, but what often times happens is the issuance of new stock which will dilute the existing shareholders. So once again we see a high risk and possible high reward scenario developing with this stock as they move into Phase III.

If one is going to discuss cancer vaccines and groundbreaking treatments, then you have to also consider Oncothyreon (ONTY). ONTY is a biotechnology company dedicated to the development of oncology products for cancer patients. The company is focusing on the non-small-cell lung Que nous dit la bourse ? 307171 cancer vaccine (Stimuvax). ONTY has partnered with Merck KGaA of Darmstadt, Germany, who is developing Stimuvax under a license agreement. There are two Phase III trials of Stimuvax underway, and interim results are due by the end of this year.

Excitement for ONTY comes from many aspects of the company, but one particular event dealt with the clinical data relating to long-term treatment with Stimuvax. The data was presented at the International Association for the Study of Lung Cancer's 13th World Conference on Lung Cancer in San Francisco on August 1, 2009. This study involved 16 patients who received treatment with Stimuvax between 2 and 8.2 years as part of the Phase IIb trial in patients with Stage IIIb and Stage IV non-small-cell lung cancer. Results were that 10 of the 16 patients were alive without evidence of disease progression, of whom eight continued to receive therapy with Stimuvax after 6.3 to 8.2 years. To add to this, the remaining two patients discontinued Stimuvax therapy after 2.4 and 5.8 years, and were also without evidence of disease progression. Though it was not a 100% success rate, the results were positive.

10 des 16 patients étaient encore vivants sans progression de la maladie, parmi lesquels 8 continuaient à recevoir la thérapie Stimuvax après 6.3 ans et 8.2 ans sans progression de la maladie. Même si ce n'est pas 100% de réussite, les résultats sont quand même positifs...

Earlier in the year the company raised $43 million at a public offering of 11.5 million shares of stock at $4 per share. As of August 1, 2011, the shares traded as high as $8.36, and in mid-July where trading in the $10 range, so there is some excitement building in ONTY. As of June 30, 2011, the company incurred a net loss of $41.1 million for the six months ended June 30, 2011, compared to a net loss of $5.1 million for the same period in 2010. The increase in net loss was primarily due to the increase in fair value of warrant liability, which was primarily attributable to the increase in the price of their common stock. Needless to say, the introduction of cancer vaccines can easily change the way medicine is practiced when dealing with deadly cancers.

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Keryx Biopharmaceuticals, Inc (KERX) is a biopharmaceutical company focused on the acquisition, development and commercialization of medically important pharmaceutical products for the treatment of life-threatening diseases, including cancer and renal disease. KERX’s product that may have a major impact in the world of medicine is their drug Perifosine, which is their oral anti-cancer drug. The drug is designed to treat advanced colorectal cancer Que nous dit la bourse ? 307141. KERX secured Perifosine via a commercial license agreement in 2002 with Zentaris AG, which is a wholly owned subsidiary of AEterna Zentaris Inc.

It should be stated that, according to the American Cancer Society, colorectal cancer is the third most common form of cancer diagnosed in the United States. It is estimated that over 141,000 people will be diagnosed with some form of colorectal cancer in the United States, with over 49,000 patients dying from colorectal cancer in 2011. Surgery is often the main treatment for early-stage colorectal cancer.

If KERX can bring their drug to market with successful testing, it could easily become a very popular treatment in helping the fight against colon cancer. Recently the company stated that they made significant progress in their Phase III programs and they had completed the enrollment of Perifosine's Phase III program in advanced refractory colorectal cancer. More exciting news is that if the trials are successful, Perifosine may be used on several different types of cancer other than colorectal.

La perifosine pourra être utilisé sur différents types de cancer autre que le cancer du Que nous dit la bourse ? 307141

At June 30, 2011, the company had cash equivalents, interest receivable and investment securities of $52.5 million, as compared to $28.5 million at December 31, 2010. In May 2011, the company completed an underwritten registered offering of common stock, which provided proceeds to the company of approximately $30.8 million. The net loss for the second quarter ended June 30, 2011, was $3.1 million, compared to a net loss of $5.2 million for the second quarter in 2010, representing a decrease in net loss of $2.1 million. The three months ended June 30,
2011 included license revenue of $5.0 million, related to a milestone payment from the company's Japanese partner for Zerenex (ferric citrate), Japan Tobacco Inc. and Torii Pharmaceutical Co., Ltd., for their commencement of a Phase III clinical program of ferric citrate in Japan. Management also stated that since the solidifying of the balance sheet with the $33 million registered offering, they believe they are well capitalized to execute on their business plan. It will be an exciting time for KERX as the future unfolds.

The last company represents the new wave of regenerative medicine via stem cells. This company is Advanced Cell Technology (ACTC), and has some exciting technologies lined up. ACTC is a biotechnology company that specializes in the development of cellular therapies based on stem cell technologies (both adult and human embryonic). The company has developed and holds patents on the first-ever proven alternative method for successful stem cell generation without harm to the embryo, called the “single-cell blastomere” technique. Add to this there are three cellular product platforms based on groundbreaking stem cell technology which are as follows:

The company is focused on commercializing its human embryonic stem cell (hESC)-based Retinal Pigment Epithelial (RPE) therapy for degenerative retinal disease, for which it has recently secured two FDA clearances for Phase 1/2 clinical trials for which it recently initiated two Phase 1 clinical trials.

The company is also developing its human embryonic stem cell (hESC)-basedHemangioblast (HG) platform for the treatment of blood and cardiovascular diseases. The company is developing this program in partnership with CHA Biotech of Korea.
The company is focused on advancing its Phase II-approved Myoblast autologous adult stem cell therapy for the treatment of chronic heart failure, advanced cardiac disease, myocardial infarction, and ischemia.

For the period ended June 30, 2011, the company had revenue of approximately $0.2 million which was generated through license fees and royalty payments. Research and Development expenses for the three months ended June 30, 2011, and 2010 were $1.53 million and $1.48 million. The company reported a loss from operations of $(3.6) million, compared to a loss from operations of $(1.1) million in the 2010 second quarter.

Net cash used in operations for the 2011 second quarter was $3.2 million, compared to net cash used in operations of $1.8 million in the same period in 2010. The net cash used in operations increased as a result of the company preparing for, and commencing, its clinical trials. The company ended the 2011 second quarter with cash and cash equivalents of $16.1 million, compared to $13.7 million as of March 31, 2011 after drawing down approximately $4 million from its available equity commitment.

If the company can successfully execute on any one of the three platforms, it will definitely be a game-changer in the world of medicine. The risk is if the company will have enough cash to see the trials through to the end, as any further dilution to the large number of outstanding shares will be seen as a big negative.

In conclusion, the above companies all have drugs and technologies that could truly change the world of medicine. The risks are high, and any failure or misstep could easily lead to catastrophic losses for anyone holding the shares. On the other hand, success by the company could generate returns that most investors can only dream about. Obviously this article was only able to focus on a select few companies, and there are many more out there to look at. Before investing, make sure to complete all the necessary research as these companies can -- and will -- be volatile.

Disclosure: I am long KERX, RXII.
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